The anterior only approach using the ARCH system is as effective as the combined anterior and posterior approach and is less traumatic in treating lumbosacral tuberculosis.
We synthesized and evaluated the immunostimulatory capacity of a library aryl trehalose derivatives and evaluated the structure activity relationship of the compounds in terms of the ability of compounds to engage the Mincle receptor, induce production of innate cytokines from human and murine cells, induce a pro-Th17 cytokine profile from primary human peripheral blood mononuclear cells and demonstrated efficacy in generating antibodies in combination with a tuberculosis antigen M72 in a mouse model.
Foreign nationality, non-Chinese ethnicity, and age above 40 years were independently associated with baseline LTBI, whereas having >2 TB exposure episodes and working in internal medicine, medical subspecialties, and psychiatry wards were associated with QFT-GIT conversion.
We report the case of successfully treated a patient with reactive arthritis induced by active extra-articular tuberculosis with a TNF inhibitor after sufficient antitubercular treatment.
SNORD104 expression decreased during <i>M. tuberculosis</i> infection of primary human peripheral blood mononuclear cells (PBMC) and M2-like (<i>P</i> = 0.03) but not M1-like (<i>P</i> = 0.31) macrophages, suggesting that its downregulation in peripheral blood in TB is biologically relevant.
It has been reported previously that the catalytic subunit of protein phosphatase 2A (PP2Ac) is crucial for regulating AMP-activated protein kinase (AMPK)-mediated autophagic signaling pathways, yet its role in tuberculosis is still unclear.Here, we demonstrated that <i>M. bovis</i> infection increased PP2Ac expression in murine macrophages, while nilotinib a tyrosine kinase inhibitor (TKI) significantly suppressed PP2Ac expression.
A Novel Genetic Variation in <i>NCF2</i>, the Core Component of NADPH Oxidase, Contributes to the Susceptibility of Tuberculosis in Western Chinese Han Population.
We found that the rs10911362 variants were associated with a decreased TB risk in this population (odds ratio [OR<sub>G</sub>] = 0.83 [0.72-0.95], OR<sub>add</sub> = 0.83 [0.72-0.95], OR<sub>dom</sub> = 0.78 [0.66-0.93], <i>p</i> < 0.05). rs10911362 might fall in a transcriptional factor binding site associated with ZNF410 and may be the expression quantitative trait loci (eQTL) for the SMG7 gene according to the Ensembl data.
We found that the rs10911362 variants were associated with a decreased TB risk in this population (odds ratio [OR<sub>G</sub>] = 0.83 [0.72-0.95], OR<sub>add</sub> = 0.83 [0.72-0.95], OR<sub>dom</sub> = 0.78 [0.66-0.93], <i>p</i> < 0.05). rs10911362 might fall in a transcriptional factor binding site associated with ZNF410 and may be the expression quantitative trait loci (eQTL) for the SMG7 gene according to the Ensembl data.
In our study, we aimed at investigating the association of polymorphisms in neutrophil cytosolic factor 2 (<i>NCF2</i>) gene, the core component of NADPHO, with susceptibility of TB in the Western Chinese Han population.
In our study, we aimed at investigating the association of polymorphisms in neutrophil cytosolic factor 2 (<i>NCF2</i>) gene, the core component of NADPHO, with susceptibility of TB in the Western Chinese Han population.
In our study, we aimed at investigating the association of polymorphisms in neutrophil cytosolic factor 2 (<i>NCF2</i>) gene, the core component of NADPHO, with susceptibility of TB in the Western Chinese Han population.
The role of African predominant SLCO1B1 variant alleles on rifampicin pharmacokinetics and the subsequent effect on the occurrence of Mycobacterium tuberculosis-rifampicin sensitivity needs to be defined.
BCG-infection also induced the expression of TNF receptor 2 on CD3<sup>+</sup> myeloid cells, which increased after BCG-infection, suggesting that the tmTNF/TNFRs axis plays an important role in the presence or function of these cells in tuberculosis.
The WHO-endorsed immunodiagnostic Alere Determine Lipoarabinomannan Ag-test (LAM-test) detects Mycobacterium tuberculosis complex LAM in urine, and its use is recommended for TB diagnosis among HIV co-infected individuals with low CD4 T-cell counts.
The WHO-endorsed immunodiagnostic Alere Determine Lipoarabinomannan Ag-test (LAM-test) detects Mycobacterium tuberculosis complex LAM in urine, and its use is recommended for TB diagnosis among HIV co-infected individuals with low CD4 T-cell counts.
Most of the compounds showed significant activity against Mycobacterium tuberculosis H37Rv strain with minimum inhibitory concentration (MIC) values in 20-40 μM range in GAST/Fe medium when compared with triclosan (43 μM) in the first week of assay, and after additional incubation, seven compounds, that is, 2a, 2c, 2g, 2h, 2i, 2j, and 2m, exhibited MIC values at the concentration of 20-40 μM.
After 24 hr ESAT-6 1 <i>μ</i>g/ml stimulation, the percentage of IL-1b-expressed hMDM was borderline lower in the active TB patients (<i>n</i> = 9) than in the LTBI cases (<i>n</i> = 10) (14.0 ± 11.2% vs. 31.6 ± 22.5%, <i>P</i> = 0.065).